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The role of Aph1 as being a scaffold in complex formation is perfectly-regarded [9,34,35]. as the mutation located in this study could have also influenced complex development, we examined the quantity of advanced by immunoprecipitation. The quantities of Aph1aL and PS1 fragments (NTF or CTF) during the intricate were being identical in the Aph1aL WT and mutant in yeast and MEF cells.

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